Dan - you're going to love this reply... To the best of my knowledge, movement of street centerlines won't break any of our applications (as in software applications). However, it will result in our data breaking the data quality rules we have set up for those 10-ish layers.
But... In reality, there is no way for us to enforce those rules now anyway. Since we don't maintain street centerlines, how are we to know if the centerlines move? At one time someone went through and snapped each of those layers to the centerlines. But, I suspect (am fairly certain even) that the centerlines have moved in places since then and we didn't know about it. Thus, our data is already breaking our data quality rules. Other than running complicated GDB topology checks every time we get a basemap delivery, there is no way to confirm coincidence of our layers with the centerlines. In essence, we have ordinances and other formal documents that state that certain boundaries are located along such and such street - but how do we operationalize that in GIS? I'm guessing it's pretty much the same for you and Zoning.
All I can say is 1) we do the best we can and 2) do what you need to to adactl (street centerlines) and Boise City will work with it. At least that's my opinion. Thanks for keeping us posted on changes!